The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Man Spends $70K To Tattoo His Full Body And Eyeballs, Reveals What He Looked Like Before
Quest Gulliford, a TikTok sensation and cancer survivor with a large tattoo collection, is causing waves with his viral video that exposes his bold dyed eyeballs in addition to his full body tattooing. It’s an astounding exhibition of individualism.
Successfully overcoming Hodgkin’s lymphoma, Gulliford has spent an incredible $70,000 on tattoos since starting his adventure in 2009. In his most recent TikTok video, he describes going through an eyeball tattoo, an experience that needed a great deal of mental preparation. It takes viewers on a visceral journey.
Gulliford stated, “It was definitely high risk, high reward, especially since I’ve wanted it done for so long,” in reference to the procedure’s high stakes. and after three years, I’m still really pleased with it.
He has spent over $70,000 on his distinctive style of self-expression, of which $10,000 is devoted to the modification of his eyes alone.
Gulliford acknowledged, “It took me a long time actually on the day once I walked into the shop to even psych myself up to get it done,” when describing the mental toughness needed on the day of the eyeball tattoo in Houston, Texas. In this non-traditional process, which is more like an injection or alteration than a normal skin tattoo, a needle is inserted into each side of the eyeball.
Unexpectedly, Gulliford disclosed that he intends to see the same tattoo artist the following month to improve his eye ink, demonstrating his dedication to pushing the limits of personal expression.
Among the many tattoos that cover his body, Gulliford proudly sports one that represents his successful fight against cancer. Every tattoo he has, from his first, a cross with the words “God First” on his chest, to his moving purple cancer ribbon commemorating his battle with Hodgkins lymphoma in seventh grade, narrates a tale of perseverance.
Gulliford recalled his health struggle that culminated in his tattoos, saying, “I had a big lymph node growing.” I didn’t give it much thought. It was chemotherapy for around half a year. After that, I felt as though I had superhuman strength.
In a 2019 interview with Inked, Gulliford revealed that when he first started getting facial tattoos at the age of 18, his mother wasn’t happy about it. Even though she finally came around to smaller face tattoos, her qualms were aroused as ink spread onto a larger canvas, leading her to intervene at tattoo parlors to try and discourage artists from doing larger facial tattoos.
Quest Gulliford’s unabashedly honest path of self-expression, characterized by victory over hardship, never fails to enthrall audiences, demonstrating that sometimes the most amazing tales are etched on our flesh.
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